Mystic, CT (semi-remote available)
 
At Enko we believe that to create the future the world wants, we need to change the way the world grows. That is why we are on a mission to help farmers and growers provide for the planet, without it costing the Earth. Enko discovers and develops novel products for farmers to protect their crops from pests and disease. Our agricultural invention platform, Enkompass™, uses DNA encoded libraries, A.I. and machine learning [RG1] to create more effective ways of finding and selecting the right treatments for the right targets– faster than anyone had ever imagined possible. By providing farmers with new tools to grow their crops successfully and look after their land sustainably, we hope to open the door for increased adoption of other new and emerging technologies being applied to agriculture.
 
Led by a team of proven scientists, entrepreneurs, and industry veterans, Enko’s innovative
science, agile design, and discovery of new modes of action is producing next-generation crop
protection solutions that will overcome the critical challenges facing industry. The industry has taken notice and we have active projects with many key industry players…with more to come!
 
Enko is as focused on building up our team members as we are on building a great platform and products. As such, we offer a competitive benefits package including health, dental, vision, life, and disability insurance, 401(k) matching contributions, and more.
 
We are currently seeking a Software Engineer to be a foundational member of the Enko Data Science team and to play an integral role in building out our data pipelines and automated data analysis capabilities. A successful candidate will thrive in a growing and rapidly changing environment, enjoy collaborative projects, and seek to contribute to projects across the R&D portfolio. Specifically, the role has the following criteria:
 
Responsibilities:
 
·       Develop and maintain robust data ELT (extract, load, transform) pipelines and data analysis tools which support the R&D process that effectively leverage both Enko’s custom tools and Enko’s commercial packages 
·       Collaborate effectively with diverse members of the organization in software engineering, data science, and laboratory science roles to gather, validate, and refine solution requirements
·       Identify, design, implement, and test effectively scoped solutions that anticipate needs and delight users (your coworkers!)
·       Contribute to a growing collaborative code base by writing and reviewing high quality, readable, and reproducible code (primarily Python, Bash, and SQL)
 
Desired Qualifications:
 
·      B.S./M.S./Ph.D. in a quantitative STEM discipline
·      Highly proficient with developing reliable software in a professional environment; Experience with our core stack: infrastructure tools (e.g. AWS, PostgreSQL, Django, Git, Docker), and visualization tools (e.g. Matplotlib, Plotly, Dash, Seaborn)
·      Ability to learn and adapt new software tools; experience developing LIMS and or other laboratory support tools desired, but not required
·      Demonstrated success working on cross functional teams to deliver business relevant products
·      Strong analytics skills with experience displaying, analyzing, and interpreting complex data
·      Ability to drive a project from conception through development, testing, and deployment in a fast paced (and still evolving) environment
 

At Enko we believe that to create the future the world wants, we need to change the way the world grows. That is why we are on a mission to help farmers and growers provide for the planet, without it costing the Earth. Enko discovers and develops novel products for farmers to protect their crops from pests and disease. Our agricultural invention platform, Enkompass™, uses DNA encoded libraries, A.I. and machine learning to create more effective ways of finding and selecting the right treatments for the right targets– faster than anyone had ever imagined possible. By providing farmers with new tools to grow their crops successfully and look after their land sustainably, we hope to open the door for increased adoption of other new and emerging technologies being applied to agriculture. 
 
Led by a team of proven scientists, entrepreneurs, and industry veterans, Enko’s innovative 
science, agile design, and discovery of new modes of action is producing next-generation crop 
protection solutions that will overcome the critical challenges facing industry. The industry has taken notice and we have active projects with many key industry players…with more to come!  
 
Enko is as focused on building up our team members as we are on building a great platform and products. As such, we offer a competitive benefits package including health, dental, vision, life, and disability insurance, 401(k) matching contributions, and more. 

 The successful candidate will have demonstrated the ability to thrive in a dynamic, fast-paced, and innovative environment. Excellent written and oral communication skills are required, as is the desire and ability to excel in a multidisciplinary environment. As an early member of the R&D team, this person will have an opportunity to help establish a culture that nurtures scientific excellence, a sense of urgency to achieve project success, and success built on collaboration and personal accountability.
 
Major responsibilities include:
·       Apply knowledge of market leading products and the attributes of highly effective insecticides to define characterization strategies that support advancement of chemistries through the staging system.
·       Lead the design and implementation of robust assays for characterization of candidate chemistries on agronomically important insect pests.
·       Collaborate within multidisciplinary project teams to optimize chemistries using a hypothesis-driven approach.
·       Collaborate with external partners to conduct advanced characterization of candidate molecules
·       Collaborate with a diverse team of scientists to identify and validate molecular targets for new Hit generation experiments.
 
The ideal candidate will have demonstrated an ability to apply their expertise in insecticide discovery to advance small molecule discovery campaigns from screening to identification of development candidates. They will have a deep understanding of the discovery process and be able to translate this to the development of a tiered evaluation system for insecticides.
 
 
Qualifications and Skills:
·       Ph.D. (or M.S. + additional experience) in Entomology, Toxicology, Physiology or a related discipline.
·       A minimum of 5 years of experience in the discovery of small molecule insecticides including direct involvement the characterization of early-stage chemistries in the lab and greenhouse.  A working knowledge of the characterization of crop protection chemistries in the field is desirable.
·       Experience in utilizing data-driven decision making to advance chemistries in a staged, pipeline management system.
·       Demonstrated ability to work as part of a team.
·       Excellent written and oral communication.
·       Experience in establishing and managing external research collaborations.
·       Understanding of the properties necessary in a small molecule insecticide including a working knowledge of organic chemistry necessary to contribute to a multidisciplinary team.
 

Enko Chem is a venture-backed start-up in Mystic, CT committed to addressing the needs of a growing world population by advancing the discovery and development of new crop protection chemistries. 
 
The Facility & Maintenance Manager is responsible for maintenance, operation, and security of the Enko building and grounds, as well as the planning and implementation of capital improvement projects to support Enko’s research and development.  This person will proactively foster Enko’s culture of safety for all employees and contractors.
 
The duties of the Facility & Maintenance Manager includes project management, procurement & contract management, budgeting, energy tracking, collaboration with R&D and Leadership, oversight of the maintenance and custodial care of the facility, maintaining the facility in a safe condition, and emergency response. 
 
 
Facilities Maintenance
 
Track inventory, conditions of, and services provided to Enko’s building systems (example:  HVAC or security systems including condition, repair, and life expectancy).  Evaluate and implement a multi-year preventive maintenance plan for all critical facility assets, including a system to prioritize maintenance projects.  Supervise response and tracking of maintenance requests (work orders).
 
Oversee daily operation of HVAC, electrical, and plumbing systems, using building electronic system controls as needed.  Implement improvements to these control systems as needed.
Be on site to inspect buildings in response to weather emergencies or unplanned events.
 
 
Capital Projects
 
Develop and maintain capital improvement plans as directed by Enko management.  Prepare specifications for work that will be completed both internally and under contract.  Inspect and provide progress reports on construction, repair, and renovation work.  Ensure that all work is procured in accordance with state and local law and Company policies.
 
 
Safety and Security
 
Monitor security systems and procedures, including video surveillance and access control, and safety systems such as fire alarms and equipment alarms.  Ensure appropriate training to end users of these systems.
 
 
Financial Management
 
Work with Enko’s Finance and Accounting team to establish detailed bid and quote specifications pertaining to larger equipment purchases and/or capital projects.
 
Actively monitor the department’s current operating budget and conduct a cost analysis of facilities expenditures as a basis for future budgets.  Estimate equipment replacement costs and develop forecasts.
 
 
Partnership and Collaboration
 
Establish strong relationships with facility stakeholders especially R&D and greenhouse management and staff.  Provide input as needed for the coordination of activities and projects in the Enko facility. 
 
In addition to the functions above, the candidate must perform other duties, tasks, and responsibilities as assigned by the VP Operations. 
 
 
QUALIFICATIONS
 
Required:  Bachelor's degree in Engineering, Facilities Management, Construction Management or related field.
 
Five (5) or more years of progressively responsible experience that is directly relevant for performing the functions of the job including working knowledge of at least three trades is required (maintenance, plumbing, electrical, HVAC systems, carpentry, construction) or  certification in industrial HVAC, electrical, or plumbing.
 
Supervisory and administrative experience.
 
Experience with computerized maintenance management systems (e.g., Maintenance Connection) and/or building management systems (e.g., Desigo) preferred.
 

At Enko we believe that to create the future the world wants, we need to change the way the world grows. That is why we are on a mission to help farmers and growers provide for the planet, without it costing the Earth. Enko discovers and develops novel products for farmers to protect their crops from pests and disease. Our agricultural invention platform, Enkompass™TM, uses DNA encoded libraries, A.I. and machine learning to create more effective ways of finding and selecting the right treatments for the right targets, faster than anyone had ever imagined to be possible. By providing farmers with new tools to grow their crops successfully and look after their land sustainably, we hope to open the door for increased adoption of other new and emerging technologies being applied to agriculture. 
 
Led by a team of proven scientists, entrepreneurs, and industry veterans, Enko’s innovative 
science, agile design, and discovery of new modes of action is producing next-generation crop 
protection solutions that will overcome the critical challenges facing industry. The industry has taken notice and we have active projects with many key industry players…with more to come!  
 
At Enko we are as focused on building up our team members as we are on building a great platform and products. As such, we offer a competitive benefits package including health, dental, vision, life, and disability insurance, 401(k) matching contributions, and more. 
 
We are currently seeking a Scientist/Sr Scientist Computational Chemistry (title commensurate with experience) to be a foundational member of the Enko Data Science team and to play an integral role in building out our computer aided drug design and virtual screening capabilities. A successful candidate will thrive in a growing and rapidly changing environment, enjoy collaborative projects, and seek to contribute to projects across the R&D portfolio. Specifically, the role has the following criteria: 
 
Responsibilities: 

• • Collaborate with interdisciplinary teams to support hit discovery and lead optimization by leveraging expertise in computer aided drug design (CADD) methods. 
  • Drive the growth and refinement of Enko’s technical capabilities around CADD methods. Champion new methods and approaches, identify emerging opportunities, and serve as a subject matter expert on project teams. 
  • Perform structural analysis to evaluate new targets (e.g., druggability analysis, selectivity analysis, sequence analysis, etc.), and rationalize ligand binding with observed Structure Activity Relationships 
  • Generate compound proposals using computational methods (e.g., virtual library construction, structure-based screening, ligand-based screening, pharmacophore methods, etc.). 
  • Write new scripts/code to implement workflows that enable large-scale analyses of compounds and targets 

 
Desired Qualifications: 
(Note that these qualifications are intended as a guide, and we are open to candidates who meet some, but not all, provided they can succeed in the responsibilities of the role) 

• • Ph.D. in computational chemistry, structural biology, or related computational discipline 
  • Professional experience in drug or pesticide discovery/development 
  • Professional experience working with diverse, interdisciplinary teams including chemists, biologists, data scientists, software engineers, etc. 
  • Working knowledge of contemporary synthetic organic chemistry and a deep understanding of the principles underlying intimate molecular recognition events 
  • Experience with the hit to lead process from high throughput screening, DNA encoded library screening, or similar 
  • Expert knowledge in computational chemistry principles, including both structure-based and ligand-based methods  
  • Demonstrated expertise in using multiple commercial and/or academic molecular modeling packages (such as Schrodinger, Cresset, OpenEye, etc.) 
  • Fluency in one or more programming/scripting languages (e.g., Python, Bash, etc.), cheminformatics/data science tools (e.g., RDKit, Pandas, SKlearn, etc.) and experience working with cloud computing resources (e.g., AWS).  
  • A passion for writing reusable and reproducible data analysis pipelines and experience with tools (e.g., Docker, Data Version Control, etc.). 
  • Expertise in applying machine learning methods to enable compound discovery and design.

 Enko Chem is a venture-backed start-up in Mystic, CT  committed to addressing the needs of a growing world population by advancing the discovery and development of new crop protection chemistries.  We have a team of scientists who collaborate internally and externally to move discoveries from the laboratory to the field and are searching for an experienced scientist with a background in analytical chemistry to join the team with responsibility for characterizing early-stage compound activity on model and target weeds, crop pathogens, and insects.
 
Major responsibilities include:
·       Employ expertise in analytical chemistry to qualitatively and quantitatively generate results used to guide development of structure activity relationship (SAR) along with environmental and biological (ADME) fate for early- to mid-stage chemistries. 
·       Collaborate as a member of project teams to develop approaches for rapidly and reliably advancing early-stage chemistries through a tiered evaluation system
·       Preparation of technical reports and summaries for group members, project teams, and senior management 
Share results, skills, and knowledge in a team-based environment, including as a member of multidisciplinary project teams in the discovery and optimization of herbicide , fungicide, insecticide and nematicide candidates
Manage and direct external collaborators and contract research (CROs) to extend Enko’s research capability
Maintain timely and accurate lab records. Follow all Environmental, Health & Safety laboratory safety standards and maintain company compliance requirements
 
The successful candidate will have demonstrated the ability to thrive in a dynamic, fast-paced, and innovative environment. Excellent written and oral communication skills are required, as is the desire and ability to excel in a multidisciplinary environment. As a member of a growing R&D team, this person will have an opportunity to contribute to a culture that nurtures scientific excellence, a sense of urgency to achieve project success, and success built on collaboration and personal accountability.
 
Qualifications and Skills
·       BS or MS with 10+ years of relevant experience or Ph.D. with 6+ years in Analytical Chemistry, Biochemistry, or a related discipline
·       Preference will be given to candidates with two or more years postdoctoral research or relevant industry experience, preferably including direct involvement characterizing early-stage crop protection chemistries and/or pharmaceuticals
·       Self-starter with the ability to independently conceive and implement a research strategy to characterize early-stage compounds 
·       Hands-on expertise in a range of analytical techniques (e.g., HPLC, GC, MS, NMR) for characterizing and quantifying compounds and metabolites, and the ability to analyze, visualize and interpret results
·       Strong background in small molecules is required and familiarity with crop protection literature is desired, particularly in the areas of herbicide and fungicide MOA and metabolism 
·       Experience establishing and managing external research collaborations